Exenatide is based on exendin-4, a peptide found in Gila monster saliva, whilst semaglutide is a modified version of human GLP-1
It has been proven that glucagon-like peptide-1 receptor (GLP-1R) agonists control blood glucose concentrations through a multitude of mechanisms, such as increased satiety, slow stomach emptying, decreased glucagon secretion, and increased insulin synthesis/secretion
Timothy Garvey, Matthias Blher, et al
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The ROS produced upon engagement of these receptors can then alter downstream signaling by oxidizing specific cysteine residues within a variety of intracellular proteins including protein kinases, protein phosphatases, adaptor proteins, calcium channels, and transcription factors
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